|
Assistant Professor
Education
Ph.D., Pharmacology / Toxicology - Virginia Commonwealth University
B.S., Biochemistry - Lynchburg College
Postdoctoral Training
Postoctoral Fellowship, Virginia Commonwealth University
Awards
National Research Service Award – Postdoctoral Fellowship, 1998-2001
Central Virginia Chapter-Society for Neuroscience-Travel Award, 1995
Virginia Commonwealth University Graduate Fellowship Award
Professional Societies
Society for Neuroscience
International Cannabinoid Research Society
Central Virginia Chapter Society for Neuroscience
Current Grants
Co-investigator, Status Epilepticus Reorganizes Cannabinoid Receptors, NIH NINDS RO1
Co-investigator, Pathophysiology and Mortality of Status Epilepticus, NIH NINDS RO1
Co-investigator, Counter Measures against Acetylcholine Receptor Activated Status Epilepticus, NIH NINDS UO1
Recent Publications
Blair RE, Deshpande LS, Sombati S, Martin BR, DeLorenzo RJ. Prolonged exposure to
WIN 55,212-2 results in increased frequency of seizure discharges in the
hippocampal neuronal culture model of acquired epilepsy, (in preparation).
Blair RE, Carter DS, Sombati S, DeLorenzo RJ. CaM kinase II knockdown cauases
increased endocytosis and decreased function of the GABAA receptor that results in
epileptiform activity in cultured hippocampal neuronos, (in preparation).
Blair, RE, Sombati, S, Churn, SB and DeLorenzo, RJ. N-methyl-d-aspartate
receptor/Ca2+-dependent decrease in neuronal Ca2+/calmodulin-dependent protein
kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent
epileptiform discharges, Eur. J. Pharm. (In Press).
Carter DS, Harrison AJ, Falenski KW, Blair RE and Delorenzo RJ. Long term decrease in
calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine
induced status epilepticus. Epilepsy Res. (In Press).
Deshpande LS, Lou, JK, Mian, A, Blair RE, Sombati S, DeLorenzo RJ. Time course and
mechanism of hippocampal neuronal death in an in vitro model of status epilepticus:
Role of NMDA receptor activation and NMDA dependent calcium entry. Eur J
Pharmacol., 583: 73-83, 2008.
Deshpande LS, Lou, JK, Mian, A, Blair RE, Sombati S, DeLorenzo RJ. In vitro status
epilepticus but not spontaneous recurrent seizures cause cell death in cultured
hippocampal neurons. Epilepsy Res., 75(2-3):171-9, 2007.
DeLorenzo, RJ, Sun, DA, Blair RE and Sombati, S. An in vitro model of stroke-induced
epilepsy: elucidation of the roles of glutamate and calcium in the induction and
maintenance of stroke-induced epileptogenesis. Int Rev Neurobiol., 81:59-84, 2007
(Review).
Falenski KW, Blair RE, Sim-Selley LJ, Martin BR, DeLorenzo RJ. Status epilepticus
causes a long-lasting redistribution of hippocampal cannabinoid CB1 receptor
expression and function in the rat pilocarpine model of acquired epilepsy.
Neuroscience, 146, 1232-1244, 2007.
Raza M., Deshpande L.S., Blair R.E., Carter D.S., Sombati S., DeLorenzo R.J.. Aging is
associated with elevated intracellular calcium levels and altered calcium homeostatic
mechanisms in hippocampal neurons. Neurosci Lett. 2007 May 11;418(1):77-81.
Deshpande L.S., Blair R.E., Nagarkatti N., Sombati S., Martin B.R., DeLorenzo R.J.
Development of pharmacoresistance to benzodiazepines but not cannabinoids in the
hippocampal neuronal culture model of status epilepticus. Exp. Neur., 2007 Jan 9;
[Epub ahead of print].
|
