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Assistant Professor , Neurology
Education
Ph.D. (Biochemsitry
and Molecular Biophysics) Virginia Commonwealth University,
Richmond, Virginia, 1994
M.S. (Administration
of Justice and Public Safety) Virginia Commonwealth University,
Richmond, Virginia, 1987
B.S. (Animal Science/Poultry
Science) Virginia Polytechnic Institute and State University,
Blacksburg, Virginia, 1981
Postdoctoral
Training
Postdoctoral Fellow,
Department of Neurology, Virginia Commonwealth University,
Richmond, Virginia, 1994-1998
Postdoctoral Fellow, Department of
Neurosurgery, Virginia Commonwealth University, Richmond,
Virginia, 1998-2001
Research Interests
Understanding the mechanisms of brain damage. Specific focuses on bilirubin neurotoxicity in neonates, traumatic brain injury and epilepsy.
Recent
Publications
Rice, A., Rafiq, A., Shapiro, S.M., Jakoi, E.R., Coulter, D.A., DeLorenzo, R.J., “Long-Lasting Reduction of GABAA Receptor Function and Subunit mRNA Expression in a Model of Temporal Lobe Epilepsy”. Proc.Natl.Acad.Sci.USA, 1996, 93:9665-9669.
Rice, A.C. and DeLorenzo, R.J., “Kindling Induces Long-Term Changes in Gene Expression”, Kindling 5, Eds. M. Corcoran and S. Moshe, Plenum Press, 1998, 267-284.
Rice, A.C. and DeLorenzo, R.J. “NMDA Receptor Activation During Status Epilepticus is Required for the Development of Epilepsy”, Brain Research, 1998, 782:240-247.
Rice, A.C., Floyd, C.L., Lyeth, B.G., Hamm, R.J., DeLorenzo, R.J. “Status Epilepticus (SE) Causes Long-Term NMDA Receptor Dependent Behavioural Changes and Cognitive Deficits”, Epilepsia, 1998, 39(11):1148-1157.
Rice, A.C., and DeLorenzo, R.J., “N-Methyl-D-Aspartate Receptor Activation Regulates Refractoriness of Status Epilepticus to Diazepam”, Neuroscience, 1999, 93(1):117-123.
Morris, T.A., Jafari, N., Rice, A.C., DeLorenzo, R.J., “Persistent Increased DNA-Binding and Expression of Serum Response Factor are Associated with Long-Term Plasticity Changes”, J. Neuroscience, 1999, 19(19):8234-8243.
Kochan, L. D., Churn, S.B., Omojokun O., Rice, A., DeLorenzo, R.J., “Status Epilepticus Results in an NMDA Receptor-Dependent Inhibition of Ca2+/Calmodulin-Dependent Kinase II Activity in the Rat”, Neuroscience, 2000, 95(3):735-743.
Chen, T., Qian, Y-Z., Di, X., Rice, A., Zhu, J-P., Bullock, R. “Lactate/Glucose Dynamics After Rat Fluid Percussion Brain Injury”, J. Neurotrauma, 2000, 17(2):135-142.
Chen, T., Qian, Y-Z., Di, X., Rice, A., Zhu, J-P., Bullock, R., “Brain Lactate Uptake Increases at the Site of Impact, after Traumatic Brain Injury”, Brain Res., 2000, 861:281-287.
Clausen, T., Zauner, A., Levasseur, J.E., Rice, A.C., Bullock, R., “Induced Mitochondrial Failure in the Feline Brain: Implications for Understanding Acute Post-Traumatic Metabolic Events?”, Brain Res., 2001, 908:35-48.
Alessandri, B., Rice, A.C., Levasseur, J., DeFord, M., Hamm, R.J., Bullock, R., “Cyclosporin A Improves Brain Tissue Oxygen Consumption and Learning/Memory Performance After Lateral Fluid Percussion Injury in Rats”, J.Neurotrauma., 2002, 19:829-841.
Rice, A.C., Zsoldos, R., Chen, T., Wilson, M.S., Alessandri, B., Hamm, R.J., Bullock, M.R., “Lactate Administration Attenuates Cognitive Deficits Following Traumatic Brain Injury”, Brain Res, 2002, 928:156-159.
DeFord, S.M., Wilson, M.S., Rice, A.C., Clausen, T., Rice, L.K., Barabnova, A., Bullock, R., Hamm, R.J., “Repeated mild head injuries result in cognitive impairment in B6C3F1 mice”, J. Neurotrauma, 2002, 19:427-438.
Zauner, A., Clausen, T., Alves, O.L., Rice, A., Levasseur, J., Young, H.F., Bullock, R., “Cerebral metabolism after fluid-percussion injury and hypoxia in a feline model”, J. Neurosurg, 2002, 97:643-649.
Rice, A.C., Khaldi, A., Harvey, H.B., Salman, N., White, F., Fillmore, H., Bullock, M.R., “Proliferation and Neuronal Differentiation of Mitotically Active Cells Following Traumatic Brain Injury”, Exp Neurol, 2003, 183:406-417.
Rice, A.C., Bullock, M.R., Shelton, K.L., “Chronic ethanol treatment transiently reduces adult neural progenitor cell proliferation”. Brain Res, 2004, 1011:94-98.
Kleindienst, A., Rice, A.C., Harvey, H.B., Müller C., Hamm, R.J., Gaab, M.R., Bullock, M.R., “Intraventricular infusion of the neurotrophic protein S100B improves cognitive recovery after fluid percussion injury in the rat.”, J. Neurotrauma, 2004, 21:541-547.
Rice, A.C., Shapiro, S.M., Biliverdin Induced Brainstem Auditory Evoked Potential Abnormalities in the Jaundiced Gunn Rat, Brain Res, 2006, 1107:215-221.
Geiger, A.S., Rice, A.C., Shapiro, S.M., Minocycline blocks acute bilirubin induced neurological dysfunction in jaundiced Gunn rats. Neonatology, 2007, 92:219-226.
Shapiro, S.M., Sombati, S., Geiger, A.S., Rice, A.C., The NMDA channel antagonist MK-801 does not protect against bilirubin neurotoxicity. Neonatology, 2007, 92:248-257.
Holloway, R., Zhou, Z., Harvey, H.B., Levasseur, J.E., Rice, A.C., Sun, D., Hamm, R.J., Bullock, M.R., Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat, Acta Neurochir (Wien), 2007, 149:919-927.
Chaniary, K.D., Baron, M.S., Rice, A.C., Wetzel, P.A., Shapiro, S.M., Electromyographic Characterization in an Animal Model of Dystonia, Movement Disorders (in press).
Rice, A.C., Shapiro, S.M., Phenylhydrazine-Induced Brainstem Auditory Evoked Potential Abnormalities in the Jaundiced Gunn Rat. Submitted to Ped Res12/07.
Rice, A.C., Shapiro, S.M., “ Apoptosis in the Gunn Rat Model of Kernicterus, in preparation.
Rice, A.C., Baron, M.S., Shapiro, S.M., “Bilirubin induced neuronal loss in the subthalamic nucleus”, in preparation.
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Chiou, V.L., Zuckoff, S.B., Rice, A.C., Shapiro, S.M., Neuroprotective effects of minocycline administered after the bilirubin insult. In preparation.
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